Target
Apoptosis regulator Bcl-2
Ligand
BDBM145037
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
Ki
3.283±n/a nM
Comments
extracted
Citation
 Bruncko, MDing, HDoherty, GAElmore, SWHasvold, LHexamer, LKunzer, ARMantei, RAPark, CSong, XSouers, AJSullivan, GMTao, ZWang, GTWang, LWang, XWendt, MD Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent  US9303025 Publication Date 4/5/2016 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM145037
Synonyms:
US8952157, 225 | US9303025, 225
Type:
Small organic molecule
Emp. Form.:
C50H60ClN7O8S
Mol. Mass.:
954.572
SMILES:
CC(=O)Nc1cccc(Oc2cc(ccc2C(=O)NS(=O)(=O)c2ccc(NC3CCN(CC3)C3CCOCC3)c(c2)[N+]([O-])=O)N2CCN(CC3=C(CC(C)(C)CC3)c3ccc(Cl)cc3)CC2)c1 |t:53|
Structure:
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