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Target
Cholesteryl ester transfer protein
Ligand
BDBM192309
Substrate
n/a
Meas. Tech.
CETP Inhibition Assay
Temperature
310.15±n/a K
IC50
279.1±n/a nM
Comments
extracted
Citation
 Kawai, Y; Iwase, N; Kikuchi, O; Takata, K; Motoyama, T; Hagihara, M Acid addition salt of substituted pyridine compound US Patent  US9321747 Publication Date 4/26/2016 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM192309
Synonyms:
US9187450, 55 | US9321747, 21
Type:
Small organic molecule
Emp. Form.:
C41H42F6N4O3
Mol. Mass.:
752.7876
SMILES:
CC1(C)C[C@H](O)c2c(C1)nc(C1CCN(CC1)c1ncc(cn1)-c1cccc(c1)C(O)=O)c([C@@H](F)c1ccc(cc1)C(F)(F)F)c2C1CCC(F)(F)CC1 |r|
Structure:
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