Reaction Details Report a problem with these data
Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM225691
Substrate
n/a
Meas. Tech.
ScintillationProximity_Assay
IC50
631±n/a nM
Citation
 D3R, DD GSK TrmD D3R 226:0 (2015) [PubMed] 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
TRMD_HAEIN | trmD
Type:
n/a
Mol. Mass.:
27538.79
Organism:
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Description:
n/a
Residue:
246
Sequence:
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
  
Inhibitor
Name:
BDBM225691
Synonyms:
GTC000464A
Type:
Small Organic Molecule
Emp. Form.:
C10H15N5O
Mol. Mass.:
221.259
SMILES:
NC(=O)c1cnc(NC2CCCC2)nc1N
Structure:
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