Reaction Details Report a problem with these data
Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM225693
Substrate
n/a
Meas. Tech.
ScintillationProximity_Assay
IC50
15849±n/a nM
Citation
 D3R, DD GSK TrmD D3R 226:0 (2015) [PubMed] 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
TRMD_HAEIN | trmD
Type:
n/a
Mol. Mass.:
27538.79
Organism:
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Description:
n/a
Residue:
246
Sequence:
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
  
Inhibitor
Name:
BDBM225693
Synonyms:
GTC000466A
Type:
Small Organic Molecule
Emp. Form.:
C12H13N5O4S
Mol. Mass.:
323.328
SMILES:
Nc1nonc1C(=O)N[C@@H]1C[C@H]1c1ccc(cc1)S(N)(=O)=O
Structure:
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