Reaction Details Report a problem with these data
Target
tRNA (guanine-N(1)-)-methyltransferase
Ligand
BDBM225695
Substrate
n/a
Meas. Tech.
ScintillationProximity_Assay
IC50
1585±n/a nM
Citation
 D3R, DD GSK TrmD D3R 226:0 (2015) [PubMed] 
Target
Name:
tRNA (guanine-N(1)-)-methyltransferase
Synonyms:
TRMD_HAEIN | trmD
Type:
n/a
Mol. Mass.:
27538.79
Organism:
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Description:
n/a
Residue:
246
Sequence:
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPHYTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHNS
  
Inhibitor
Name:
BDBM225695
Synonyms:
GTC000468A
Type:
Small Organic Molecule
Emp. Form.:
C12H17N3O3
Mol. Mass.:
251.2817
SMILES:
NC(=O)c1ccc(N[C@H]2C[C@H](O)[C@@H](CO)C2)nc1
Structure:
Search PDB for entries with ligand similarity: