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Target
High affinity nerve growth factor receptor [441-796]
Ligand
BDBM226481
Substrate
n/a
Meas. Tech.
Cell Based Assay
Temperature
310.15±n/a K
IC50
2.53±n/a nM
Comments
extracted
Citation
 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS Tropomyosin-related kinase inhibitors US Patent  US9328096 Publication Date 5/3/2016 
Target
Name:
High affinity nerve growth factor receptor [441-796]
Synonyms:
MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A | Tyrosine kinase receptor A (TrkA)
Type:
Protein
Mol. Mass.:
39939.20
Organism:
Homo sapiens (Human)
Description:
Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:
356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM226481
Synonyms:
US9328096, 174
Type:
Small organic molecule
Emp. Form.:
C25H17Cl2FN8O2
Mol. Mass.:
551.359
SMILES:
Fc1cccnc1-c1cc(C(=O)Nc2cc(nn2-c2ccccc2)C(=O)NCc2cn[nH]n2)c(Cl)cc1Cl
Structure:
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