Reaction Details Report a problem with these data
Target
High affinity nerve growth factor receptor [441-796]
Ligand
BDBM226521
Substrate
n/a
Meas. Tech.
Cell Based Assay
Temperature
310.15±n/a K
IC50
3.63±n/a nM
Comments
extracted
Citation
 Bagal, SK; Cui, JJ; Greasley, SE; Lunney, EA; McAlpine, IJ; Nagata, A; Ninkovic, S; Omoto, K; Skerratt, SE; Storer, RI; Warmus, JS Tropomyosin-related kinase inhibitors US Patent  US9328096 Publication Date 5/3/2016 
Target
Name:
High affinity nerve growth factor receptor [441-796]
Synonyms:
MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A | Tyrosine kinase receptor A (TrkA)
Type:
Protein
Mol. Mass.:
39939.20
Organism:
Homo sapiens (Human)
Description:
Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:
356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM226521
Synonyms:
US9328096, 214
Type:
Small organic molecule
Emp. Form.:
C25H17ClF2N8O2
Mol. Mass.:
534.905
SMILES:
Fc1cc(Cl)c(cc1-c1ncccc1F)C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NCc1cnn[nH]1
Structure:
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