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Target
Bromodomain-containing protein 4 [44-166,I246A]
Ligand
BDBM227644
Substrate
n/a
Meas. Tech.
TR-FRET Competition Assay
pH
7.5±0
Temperature
277.15±0 K
Kd
1.71e+4± 9.8e+3 nM
Citation
 Jung, M; Philpott, M; Müller, S; Schulze, J; Badock, V; Eberspächer, U; Moosmayer, D; Bader, B; Schmees, N; Fernández-Montalván, A; Haendler, B Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1. J Biol Chem 289:9304-19 (2014) [PubMed]  Article 
Target
Name:
Bromodomain-containing protein 4 [44-166,I246A]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain protein 4 bromodomain 1 (BRD4 BD1 I146A) | HUNK1
Type:
Protein
Mol. Mass.:
14568.20
Organism:
Homo sapiens (Human)
Description:
Human BRD4 BD1 (44-166 aa) I146A mutant
Residue:
123
Sequence:
NPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNKPGDDAVLMAEALEKLFLQKINELPT
  
Inhibitor
Name:
BDBM227644
Synonyms:
Histone H4 (1-25) | MSGRGKGGKGLGKGGAKRHRKVLRD
Type:
Small organic molecule
Emp. Form.:
C108H196N44O29S
Mol. Mass.:
2607.054
SMILES:
CSCC[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(O)=O |r|
Structure:
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