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Target
Steroid 17-alpha-hydroxylase/17,20 lyase
Ligand
BDBM158429
Substrate
n/a
Meas. Tech.
CYP17-Lyase Assay
pH
7.5±n/a
IC50
1.1±n/a nM
Comments
extracted
Citation
 Bock, MG; Gaul, C; Gummadi, VR; Sengupta, S 17a-hydroxylase/C17,20-lyase inhibitors US Patent  US9339501 Publication Date 5/17/2016 
Target
Name:
Steroid 17-alpha-hydroxylase/17,20 lyase
Synonyms:
CP17A_RAT | Cyp17 | Cyp17a1 | Cytochrome P450 17,20 lyase | Cytochrome P450 17A1 | Cytochrome P450-C17 | Steroid 17-alpha-hydroxylase/17,20 lyase
Type:
Enzyme
Mol. Mass.:
57255.68
Organism:
Rattus norvegicus (Rat)
Description:
P11715
Residue:
507
Sequence:
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
  
Inhibitor
Name:
BDBM158429
Synonyms:
US9029399, 2A | US9339501, 2A
Type:
Small organic molecule
Emp. Form.:
C17H15F3N4O
Mol. Mass.:
348.3224
SMILES:
FC(F)(F)c1cc(ccn1)N1CCN(C1=O)c1cnccc1C1CC1
Structure:
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