Target
Histone demethylase UTY [818-1347,P1214I]
Ligand
BDBM231631
Substrate
n/a
Meas. Tech.
AlphaScreen Assay
pH
7.5±n/a
Temperature
298.15±n/a K
Kd
3.5e+3± 1.1e+3 nM
Comments
extracted
Citation
 Walport, LJHopkinson, RJVollmar, MMadden, SKGileadi, COppermann, USchofield, CJJohansson, C Human UTY(KDM6C) is a male-specific N¿-methyl lysyl demethylase. J Biol Chem 289:18302-13 (2014) [PubMed]  Article 
Target
Name:
Histone demethylase UTY [818-1347,P1214I]
Synonyms:
KDM6C | Lysine-specific demethylase 6C (UTY(KDM6C))(P1214I) | UTY | UTY_HUMAN
Type:
Enzyme
Mol. Mass.:
60283.28
Organism:
Homo sapiens (Human)
Description:
Human UTY(KDM6C) truncation (818-1347 aa) with P1214I mutation
Residue:
530
Sequence:
PLASHRSTSQILPSMSVSICPSSTEVLKACRNPGKNGLSNSCILLDKCPPPRPPTSPYPPLPKDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLGLFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTIAKYAQYQASSFQESLREENEKRTQHKDHSDNESTSSENSGRRRKGPFKTIKFGTNIDLSDNKKWKLQLHELTKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVERYEWNKLKSVKSIVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLSSSS
  
Inhibitor
Name:
BDBM231631
Synonyms:
Biotin-KAPRKQLATKAARKMe3SAPATGG | H3K27Me3 peptide
Type:
Small organic molecule
Emp. Form.:
C103H183N34O28S
Mol. Mass.:
2377.831
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(O)=O |r|
Structure:
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