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Target
Alpha-glucosidase MAL32
Ligand
BDBM231688
Substrate
n/a
Meas. Tech.
α-Glucosidase Inhibition Assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
5.64e+3± 5 nM
Comments
extracted
Citation
 Chaudhry, F; Choudhry, S; Huma, R; Ashraf, M; Al-Rashida, M; Munir, R; Sohail, R; Jahan, B; Munawar, MA; Khan, MA Hetarylcoumarins: Synthesis and biological evaluation as potent a-glucosidase inhibitors. Bioorg Chem 73:1-9 (2017) [PubMed]  Article 
Target
Name:
Alpha-glucosidase MAL32
Synonyms:
MAL32 | MAL32_YEAST | MAL3S | alpha-Glucosidase (α-Glucosidase)
Type:
Enzyme
Mol. Mass.:
68132.36
Organism:
Saccharomyces cerevisiae (Baker's yeast)
Description:
P38158
Residue:
584
Sequence:
MTISDHPETEPKWWKEATIYQIYPASFKDSNNDGWGDLKGITSKLQYIKDLGVDAIWVCPFYDSPQQDMGYDISNYEKVWPTYGTNEDCFELIDKTHKLGMKFITDLVINHCSTEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSFFGGSAWTFDETTNEFYLRLFASRQVDLNWENEDCRRAIFESAVGFWLDHGVDGFRIDTAGLYSKRPGLPDSPIFDKTSKLQHPNWGSHNGPRIHEYHQELHRFMKNRVKDGREIMTVGEVAHGSDNALYTSAARYEVSEVFSFTHVELGTSPFFRYNIVPFTLKQWKEAIASNFLFINGTDSWATTYIENHDQARSITRFADDSPKYRKISGKLLTLLECSLTGTLYVYQGQEIGQINFKEWPIEKYEDVDVKNNYEIIKKSFGKNSKEMKDFFKGIALLSRDHSRTPMPWTKDKPNAGFTGPDVKPWFFLNESFEQGINVEQESRDDDSVLNFWKRALQARKKYKELMIYGYDFQFIDLDSDQIFSFTKEYEDKTLFAALNFSGEEIEFSLPREGASLSFILGNYDDTDVSSRVLKPWEGRIYLVK
  
Inhibitor
Name:
BDBM231688
Synonyms:
6-Bromo-3-(4-(1-(3,5-dimethylphenyl)-4,5-diphenyl-1Himidazol- 2-yl)-1-phenyl-1H-pyrazol-3-yl)-4a,8a-dihydro-2Hchromen- 2-one (3g)
Type:
Small organic molecule
Emp. Form.:
C41H31BrN4O2
Mol. Mass.:
691.614
SMILES:
Cc1cc(C)cc(c1)-n1c(nc(c1-c1ccccc1)-c1ccccc1)-c1cn(nc1C1=CC2C=C(Br)C=CC2OC1=O)-c1ccccc1 |c:41,t:35,38|
Structure:
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