Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM233807
Substrate
n/a
Meas. Tech.
Cellular Enzyme Assay
Temperature
310.15±n/a K
EC50
48±n/a nM
Comments
extracted
Citation
 Aebi, JAmrein, KFantasia, SMHornsperger, BKuhn, BLiu, YMaerki, HPMayweg, AVMohr, PScalone, MTan, XZhou, M Bicyclic dihydroquinoline-2-one derivatives US Patent  US9353081 Publication Date 5/31/2016 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM233807
Synonyms:
US9353081, 4 | US9353081, 5 | US9353081, 6
Type:
Small organic molecule
Emp. Form.:
C21H25N3O3S
Mol. Mass.:
399.507
SMILES:
CCS(=O)(=O)NC1CCCc2c1cncc2-c1ccc2N(C)C(=O)CCc2c1
Structure:
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