Target
Nuclear receptor ROR-gamma
Ligand
BDBM293081
Substrate
n/a
Meas. Tech.
transient transactivation assay
IC50
<100±n/a nM
Citation
 Argiriadi, MABreinlinger, ECCusack, KPHobson, ADPotin, DBarth, MAmaudrut, JPoupardin, OMounier, LKort, ME Nuclear receptor modulators US Patent  US10106501 Publication Date 10/23/2018 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM293081
Synonyms:
US10106501, Example AP-1
Type:
Small organic molecule
Emp. Form.:
C26H24Cl2F3N3O3
Mol. Mass.:
554.388
SMILES:
Cc1cc(cc2n(C)c(cc12)C(=O)c1c(Cl)ccc(C(=O)N2CCN(CC2)C2COC2)c1Cl)C(F)(F)F
Structure:
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