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Target
Carbonic anhydrase 2
Ligand
BDBM236549
Substrate
n/a
Meas. Tech.
hCA Activity Assay
Ki
1.5±n/a nM
Citation
 Kaya, M; Basar, E; Cakir, E; Tunca, E; Bülbül, M Synthesis and characterization of novel dioxoacridine sulfonamide derivatives as new carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 27:509-14 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM236549
Synonyms:
4-(9-(2,4-dimethoxyphenyl)-1,8-dioxo-1,2,3,4,5,6,7,8-octahydroacridine-10(9H)-yl) benzenesulfonamide (7)
Type:
Small organic molecule
Emp. Form.:
C27H28N2O6S
Mol. Mass.:
508.586
SMILES:
COc1ccc(C2C3=C(CCCC3=O)N(C3=C2C(=O)CCC3)c2ccc(cc2)S(N)(=O)=O)c(OC)c1 |c:16,t:7|
Structure:
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