Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM236551
Substrate
n/a
Meas. Tech.
hCA Activity Assay
Ki
95±n/a nM
Citation
 Kaya, M; Basar, E; Cakir, E; Tunca, E; Bülbül, M Synthesis and characterization of novel dioxoacridine sulfonamide derivatives as new carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 27:509-14 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM236551
Synonyms:
4-(9-(4-Cyanophenyl)-2,2,7,7-tetramethyl¿1,8-dioxo¿1,2,3,4,5,6,7,8-octahydroacridine¿10(9H)-yl)benzenesulfonamide (9)
Type:
Small organic molecule
Emp. Form.:
C30H31N3O4S
Mol. Mass.:
529.65
SMILES:
CC1(C)CCC2=C(C(C3=C(CCC(C)(C)C3=O)N2c2ccc(cc2)S(N)(=O)=O)c2ccc(cc2)C#N)C1=O |t:5,8|
Structure:
Search PDB for entries with ligand similarity: