Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM237169
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay
Temperature
298.15±n/a K
Ki
<0.010±n/a nM
Comments
extracted
Citation
 Tao, Z; Wang, X; Souers, AJ; Catron, ND; Sullivan, GM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent  US9403822 Publication Date 8/2/2016 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM237169
Synonyms:
US9403822, 2
Type:
Small organic molecule
Emp. Form.:
C46H53ClN7O11PS
Mol. Mass.:
978.445
SMILES:
CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(NCC4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cn(COP(O)(O)=O)c4nccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:63|
Structure:
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