Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50149238
Substrate
4-Nitrophenyl acetate (NPA)
Meas. Tech.
Esterase Activity Assay
Ki
1.234e+4±n/a nM
Citation
 Kazancioglu, EA; Güney, M; Sentürk, M; Supuran, CT Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity. J Enzyme Inhib Med Chem 27:880-5 (2012) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50149238
Synonyms:
4-Hydroxybiphenyl | 4-Phenylphenol | 4-biphenylol | 4-diphenylol | 4-hydroxydiphenyl | Biphenyl-4-ol (8) | CHEMBL73380 | [1,1'-biphenyl]-4-ol | biphenyl-4-ol | p-biphenylol | p-hydroxybiphenyl | p-hydroxydiphenyl | p-phenylphenol | para-hydroxydiphenyl | para-phenylphenol
Type:
Small organic molecule
Emp. Form.:
C12H10O
Mol. Mass.:
170.2072
SMILES:
Oc1ccc(cc1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM11326
Synonyms:
4-nitrophenyl acetate | p-Nitrophenyl Acetate
Type:
Small organic molecule
Emp. Form.:
C8H7NO4
Mol. Mass.:
181.1455
SMILES:
CC(=O)Oc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: