Target
Angiopoietin-1 receptor [776-1124]
Ligand
BDBM239689
Substrate
n/a
Meas. Tech.
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay
pH
7±n/a
Temperature
295.15±n/a K
IC50
0.7±n/a nM
Comments
extracted
Citation
 Süβmeier, FLobell, MGrünewald, SHärter, MBuchmann, BTelser, JJöriβen, HHeroult, MKahnert, ALustig, KLindner, N Substituted phenylimidazopyrazoles and their use US Patent  US9394309 Publication Date 7/19/2016 
Target
Name:
Angiopoietin-1 receptor [776-1124]
Synonyms:
TEK | TIE2 | TIE2_HUMAN | Tyrosine-protein kinase receptor TIE-2 | VMCM | VMCM1
Type:
Enzyme
Mol. Mass.:
39865.58
Organism:
Homo sapiens (Human)
Description:
amino acids 776-1124
Residue:
349
Sequence:
NVQRRMAQAFQNVREEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLNRMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
  
Inhibitor
Name:
BDBM239689
Synonyms:
US9394309, 146
Type:
Small organic molecule
Emp. Form.:
C29H27F5N6O2S
Mol. Mass.:
618.621
SMILES:
COC1CN(C1)c1cc(cc(c1)S(F)(F)(F)(F)F)C(=O)Nc1cc(c(C)cc1C)-n1ccn2nc(cc12)-c1cccnc1
Structure:
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