Reaction Details
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Genome polyprotein [2420-3010,M2833T]
Ligand
BDBM243456
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR)-Based Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Kd
5.9±n/a nM
KOFF
1.50E-04 s-1
KON
2.60E+04 M-1s-1
Comments
extracted
Citation
Vendeville, SM; Raboisson, PJ; Lin, T; Tahri, A; Amssoms, KI Macrocyclic indole derivatives useful as hepatitis C virus inhibitors US Patent US9427440 Publication Date 8/30/2016 More Info.:
Target
Name:
Genome polyprotein [2420-3010,M2833T]
Synonyms:
POLG_HCVJ4 | RNA-directed RNA polymerase (NS5B)(M414T)
Type:
Enzyme
Mol. Mass.:
65736.12
Organism:
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
Description:
M414T
Residue:
591
Sequence:
SMSYTWTGALITPCAAEESKLPINPLSNSLLRHHNMVYATTSRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKAKLLSIEEACKLTPPHSAKSKFGYGAKDVRNLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKSEVFCVQPEKGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQAVMGSSYGFQYSPKQRVEFLVNTWKSKKCPMGFSYDTRCFDSTVTESDIRVEESIYQCCDLAPEARQAIRSLTERLYIGGPLTNSKGQNCGYRRCRASGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPINSWLGNIITYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFTLHSYSPGEINRVASCLRKLGVPPLRTWRHRARSVRAKLLSQGGRAATCGRYLFNWAVRTKLKLTPIPAASQLDLSGWFVAGYSGGDIYHSLSRARPRWFPLCLLLLSVGVGIYLLPNR
Inhibitor
Name:
BDBM243456
Synonyms:
US9427440, 1
Type:
Small organic molecule
Emp. Form.:
C32H38N4O6S
Mol. Mass.:
606.732
SMILES:
COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25|
Structure:
