Reaction Details Report a problem with these data
Target
Bone morphogenetic protein receptor type-1B
Ligand
BDBM50311017
Substrate
n/a
Meas. Tech.
Biochemical Binding Assay
IC50
107±8 nM
Kd
19±n/a nM
Citation
 Brown, BH; Carra, EA; Hemenway, JN; Morrison, H; Reynolds, T; Shi, B; Stefanidis, D; Wang, F; Warr, MR; Whitney, JA; Xin, Y (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide US Patent  US9469613 Publication Date 10/18/2016 
Target
Name:
Bone morphogenetic protein receptor type-1B
Synonyms:
ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B)
Type:
Enzyme
Mol. Mass.:
56939.41
Organism:
Homo sapiens (Human)
Description:
O00238
Residue:
502
Sequence:
MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEEDDSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVDGPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLIEQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKSMLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIVEEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPASRLTALRVKKTLAKMSESQDIKL
  
Inhibitor
Name:
BDBM50311017
Synonyms:
CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-yl)benzamide | US10112907, Example 00019 | US10766894, Compound TABLE 1.4 | US11203595, TABLE 1.4 | US9469613, CYT-0387
Type:
Small organic molecule
Emp. Form.:
C23H22N6O2
Mol. Mass.:
414.4598
SMILES:
O=C(NCC#N)c1ccc(cc1)-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
Structure:
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