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Target
Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1)
Ligand
BDBM253042
Substrate
n/a
Meas. Tech.
Inhibtion Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
545±n/a nM
Comments
extracted
Citation
 Cutshall, NS; Ferguson, KM; Zuta, CP Optically active PDE10 inhibitor US Patent  US9493447 Publication Date 11/15/2016 
Target
Name:
Isoform PDE2A1 of cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1)
Synonyms:
PDE2A | PDE2A_HUMAN | Phosphodiesterase 2A | Phosphodiesterase 2A (PDE2A) | cGMP-dependent 3',5'-cyclic phosphodiesterase (PDE2A1)
Type:
Enzyme
Mol. Mass.:
103452.51
Organism:
Homo sapiens (Human)
Description:
O00408-2
Residue:
920
Sequence:
MRRQPAASLDPLAKEPGPPGSRDDRLEDALLSLGSVIDISGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCNGLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAVEKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDLDASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVVEDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTDEDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
  
Inhibitor
Name:
BDBM253042
Synonyms:
US9493447, 1001
Type:
Small organic molecule
Emp. Form.:
C25H23ClN2O5S
Mol. Mass.:
498.979
SMILES:
CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1
Structure:
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