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Target
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)
Ligand
BDBM253042
Substrate
n/a
Meas. Tech.
Inhibtion Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
0.62±n/a nM
Comments
extracted
Citation
 Cutshall, NS; Ferguson, KM; Zuta, CP Optically active PDE10 inhibitor US Patent  US9493447 Publication Date 11/15/2016 
Target
Name:
Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)
Synonyms:
PDE10A | PDE10_HUMAN | Phosphodiesterase 10A | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase 10A2 | Phosphodiesterase 10A2 (PDE10A) | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A2)
Type:
Enzyme
Mol. Mass.:
89387.03
Organism:
Homo sapiens (Human)
Description:
Q9Y233-2
Residue:
789
Sequence:
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKADGFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIGPFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAILQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQSHRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKDEVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSVAQKAAASED
  
Inhibitor
Name:
BDBM253042
Synonyms:
US9493447, 1001
Type:
Small organic molecule
Emp. Form.:
C25H23ClN2O5S
Mol. Mass.:
498.979
SMILES:
CCOC(C(=O)c1ccc(o1)-c1cc(OC)c(Cl)c(OC)c1)c1ccc(cc1)-c1nnc(C)s1
Structure:
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