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Target
Cholesteryl ester transfer protein
Ligand
BDBM254058
Substrate
n/a
Meas. Tech.
Cholesteryl Ester Transfer Assay
IC50
1.9±n/a nM
Citation
 Lee, JK; Oh, JT; Lee, JW; Lee, SH; Kim, I; Lee, JY; Bae, SY; Lee, SR; Kim, YT Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors US Patent  US9493430 Publication Date 11/15/2016 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM254058
Synonyms:
US9493430, 684
Type:
Small organic molecule
Emp. Form.:
C37H37F6NO5
Mol. Mass.:
689.6838
SMILES:
COc1cc(C)c(cc1C1=C(CN2[C@@H](C)[C@H](OC2=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)CC(C)(C)CC1)-c1ccc(cc1C)C(O)=O |r,c:10|
Structure:
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