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Target
Mitotic checkpoint serine/threonine-protein kinase BUB1
Ligand
BDBM415284
Substrate
n/a
Meas. Tech.
Kinase Assay
IC50
4.52±n/a nM
Citation
 Graham, K; Klar, U; Briem, H; Hitchcock, M; Bärfacker, L; Eis, K; Schulze, V; Siemeister, G; Bone, W; Schröder, J; Holton, S; Lienau, P; Tempel, R; Sonnenschein, H; Bálint, J; Graubaum, H 3-amino-1,5,6,7-tetrahydro-4H-indol-4-ones US Patent  US10428044 Publication Date 10/1/2019 
Target
Name:
Mitotic checkpoint serine/threonine-protein kinase BUB1
Synonyms:
BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1
Type:
PROTEIN
Mol. Mass.:
122372.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510603
Residue:
1085
Sequence:
MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKKKYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASAVLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGNNMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKEKLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKLHQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPPVVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSGAEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTLPDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGLPQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDFTSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEKSPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQAEWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEFQLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMERLKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMRMLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGTIFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFRRLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLECKRSRK
  
Inhibitor
Name:
BDBM415284
Synonyms:
Preparation of 1-{4-[6,6-dimethyl-4-oxo-3-(phenylamino)-4,5,6,7-tetrahydro-1H-indol-2-yl]pyridin-2-yl}-3-(1-methyl-1H-pyrazol-4-yl)urea | US10428044, Example 391
Type:
Small organic molecule
Emp. Form.:
C26H27N7O2
Mol. Mass.:
469.5383
SMILES:
Cn1cc(NC(=O)Nc2cc(ccn2)-c2[nH]c3CC(C)(C)CC(=O)c3c2Nc2ccccc2)cn1
Structure:
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