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Target
Interleukin-17A
Ligand
BDBM419189
Substrate
n/a
Meas. Tech.
I L-17A Secretion
IC50
<100±n/a nM
Citation
 Musicki, B; Bouix-Peter, C; Ouvry, G; Thoreau, E Benzenesulfonamide derivatives as inverse agonists of retinoid-related orphan receptor gamma (RORγ(T)) US Patent  US10457637 Publication Date 10/29/2019 
Target
Name:
Interleukin-17A
Synonyms:
CTLA8 | Cytotoxic T-lymphocyte-associated antigen 8 | IL-17 | IL17 | IL17A | IL17_HUMAN | il-17a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
17511.44
Organism:
Homo sapiens (Human)
Description:
Q16552
Residue:
155
Sequence:
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  
Inhibitor
Name:
BDBM419189
Synonyms:
N-(4-ethylphenyl)-4-(((3- hydroxycyclobutyl)methyl) amino)-N-isobutyl-3-(S- methylsulfonimidoyl)benzene- sulfonamide | US10457637, Compound 61
Type:
Small organic molecule
Emp. Form.:
C24H35N3O4S2
Mol. Mass.:
493.682
SMILES:
CCc1ccc(cc1)N(CC(C)C)S(=O)(=O)c1ccc(NCC2CC(O)C2)c(c1)S(C)(=N)=O |(2.28,-4.62,;3.61,-3.85,;3.61,-2.31,;2.28,-1.54,;2.28,,;3.61,.77,;4.94,,;4.94,-1.54,;3.61,2.31,;4.94,3.08,;6.28,2.31,;7.61,3.08,;6.28,.77,;2.28,3.08,;2.28,4.62,;2.68,1.59,;.94,2.31,;.94,.77,;-.39,,;-1.72,.77,;-3.06,,;-3.06,-1.54,;-4.39,-2.31,;-5.88,-1.91,;-6.28,-3.4,;-7.61,-4.17,;-4.79,-3.8,;-1.72,2.31,;-.39,3.08,;-3.06,3.08,;-4.39,2.31,;-3.83,4.41,;-2.29,4.41,)|
Structure:
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