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Target
Transmembrane protease serine 2
Ligand
BDBM50239965
Substrate
n/a
Meas. Tech.
titration assay
IC50
750±n/a nM
Citation
 Lucas, JM; Heinlein, C; Kim, T; Hernandez, SA; Malik, MS; True, LD; Morrissey, C; Corey, E; Montgomery, B; Mostaghel, E; Clegg, N; Coleman, I; Brown, CM; Schneider, EL; Craik, C; Simon, JA; Bedalov, A; Nelson, PS The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis. Cancer Discov 4:1310-25 (2014) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 2
Synonyms:
PRSS10 | Serine protease 10 | TMPRSS2 | TMPS2_HUMAN | Transmembrane protease serine 2 catalytic chain | Transmembrane protease serine 2 non-catalytic chain
Type:
PROTEIN
Mol. Mass.:
53867.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_760112
Residue:
492
Sequence:
MALNSGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTSKTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRADG
  
Inhibitor
Name:
BDBM50239965
Synonyms:
Bromhexine | CHEBI:77032
Type:
Small organic molecule
Emp. Form.:
C14H20Br2N2
Mol. Mass.:
376.13
SMILES:
CN(Cc1cc(Br)cc(Br)c1N)C1CCCCC1
Structure:
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