Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase BTK
Ligand
BDBM165348
Substrate
n/a
Meas. Tech.
Btk Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.15±n/a nM
Comments
extracted
Citation
 Liu, Q; Watterson, SH; Ahmad, S Indole carboxamide compounds US Patent  US9688629 Publication Date 6/27/2017 
Target
Name:
Tyrosine-protein kinase BTK
Synonyms:
AGMX1 | ATK | Agammaglobulinaemia tyrosine kinase | Agammaglobulinemia tyrosine kinase | B cell progenitor kinase | B-cell progenitor kinase | BPK | BTK | BTK_HUMAN | Bruton tyrosine kinase | Tyrosine Kinase BTK | Tyrosine-protein kinase (BTK) | Tyrosine-protein kinase BTK (BTK)
Type:
Enzyme
Mol. Mass.:
76289.95
Organism:
Homo sapiens (Human)
Description:
Q06187
Residue:
659
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGDPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNILDVMDEES
  
Inhibitor
Name:
BDBM165348
Synonyms:
US10604504, Example 132 | US11623921, Example 132 | US9688629, 132 | US9802915, Example 132 | US9920031, Example 132
Type:
Small organic molecule
Emp. Form.:
C22H20FN3O2
Mol. Mass.:
377.4115
SMILES:
Cc1[nH]c2c(cc(F)c(-c3cccc4CN(Cc34)C(=O)C=C)c2c1C)C(N)=O |(-6.4,1.15,;-4.86,1.15,;-3.95,2.4,;-2.49,1.93,;-1.15,2.69,;.18,1.93,;.18,.38,;1.51,-.38,;-1.15,-.38,;-1.15,-1.93,;-2.49,-2.69,;-2.49,-4.23,;-1.15,-5,;.18,-4.23,;1.64,-4.71,;2.55,-3.47,;1.64,-2.22,;.18,-2.69,;4.09,-3.47,;4.86,-2.13,;4.86,-4.8,;6.4,-4.8,;-2.49,.38,;-3.95,-.09,;-4.41,-1.42,;-1.15,4.23,;.18,5,;-2.49,5,)|
Structure:
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