Target
SRSF protein kinase 1
Ligand
BDBM448661
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
4.60±n/a nM
Citation
 Bates, DMorris, JToop, HBatson, JMorley, AD Compounds US Patent  US10696661 Publication Date 6/30/2020 
Target
Name:
SRSF protein kinase 1
Synonyms:
SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Homo sapiens (Human)
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM448661
Synonyms:
N-(2-(4-(oxazol-2-ylmethyl)piperazin-1-yl)-5- (trifluoromethyl)phenyl)-5-(pyridin-4-yl)furan-2-carboxamide | US10696661, Compound 16
Type:
Small organic molecule
Emp. Form.:
C25H22F3N5O3
Mol. Mass.:
497.4691
SMILES:
FC(F)(F)c1ccc(N2CCN(Cc3ncco3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Structure:
Search PDB for entries with ligand similarity: