Target
Toll-like receptor 7
Ligand
BDBM427905
Substrate
n/a
Meas. Tech.
TLR7/8/9 Inhibition Reporter Assays
IC50
0.200±n/a nM
Citation
 Dyckman, AJDodd, DSMussari, CPSherwood, TCWhiteley, BKGilmore, JLKumar, SRPasunoori, LSrinivas, PVDuraisamy, SKHegde, SAnumula, RK 4-Azaindole compounds US Patent  US10730877 Publication Date 8/4/2020 
Target
Name:
Toll-like receptor 7
Synonyms:
ORF Names:UNQ248/PRO285 | TLR7 | TLR7_HUMAN | Toll-like receptor 7 (TLR7)
Type:
Enzyme
Mol. Mass.:
120945.35
Organism:
Homo sapiens (Human)
Description:
Q9NYK1
Residue:
1049
Sequence:
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV
  
Inhibitor
Name:
BDBM427905
Synonyms:
US10544143, Example 339 | US10544143, Example 340 | US10730877, Example 340 | US11053244, Example 340
Type:
Small organic molecule
Emp. Form.:
C28H35N7O
Mol. Mass.:
485.6238
SMILES:
COc1cc(cn2ncnc12)-c1[nH]c2cc(C)c(nc2c1C(C)C)C1CCC(CC1)N(C)CCC#N |(8.87,1.21,;7.33,1.21,;6.56,-.12,;5.02,-.12,;4.25,-1.46,;5.02,-2.79,;6.56,-2.79,;7.59,-3.93,;9,-3.31,;8.84,-1.78,;7.33,-1.46,;2.71,-1.46,;1.8,-2.7,;.34,-2.23,;-.99,-3,;-2.33,-2.23,;-3.66,-3,;-2.33,-.69,;-.99,.08,;.34,-.69,;1.8,-.21,;2.2,1.28,;1.11,2.37,;3.69,1.68,;-3.66,.08,;-5,-.69,;-6.33,.08,;-6.33,1.62,;-5,2.39,;-3.66,1.62,;-7.66,2.39,;-7.66,3.93,;-9,1.62,;-10.33,2.39,;-11.66,1.62,;-13,.85,)|
Structure:
Search PDB for entries with ligand similarity: