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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM221686
Substrate
n/a
Meas. Tech.
Amplified Luminescence Proximity Homogeneous Assay
IC50
0.700±n/a nM
Citation
 Huang, S; Jin, X; Liu, Z; Poon, D; Tellew, J; Wan, Y; Wang, X; Xie, Y Compounds and compositions as protein kinase inhibitors US Patent  US9593099 Publication Date 3/14/2017 
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
84446.00
Organism:
Homo sapiens (Human)
Description:
P15056
Residue:
766
Sequence:
MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH
  
Inhibitor
Name:
BDBM221686
Synonyms:
US10568884, Cpd 7 | US9314464, 7 | US9593100, Compound 7 | USRE49556, Compound 7
Type:
Small organic molecule
Emp. Form.:
C24H31F2N7O4S
Mol. Mass.:
551.609
SMILES:
CCCS(=O)(=O)Nc1ccc(F)c(-c2nn(cc2-c2ccnc(NC[C@H](C)NC(=O)OC)n2)C(C)C)c1F |r,wD:25.26,(6.55,-9.31,;6.95,-7.82,;5.86,-6.73,;6.26,-5.24,;4.77,-4.85,;7.74,-5.64,;6.66,-3.76,;5.57,-2.67,;5.97,-1.18,;4.88,-.09,;3.39,-.49,;2.3,.6,;2.99,-1.98,;1.5,-2.38,;1.03,-3.84,;-.51,-3.84,;-.99,-2.38,;.26,-1.47,;.26,.07,;1.59,.84,;1.59,2.38,;.26,3.15,;-1.08,2.38,;-2.41,3.15,;-2.41,4.69,;-3.74,5.46,;-5.08,4.69,;-3.74,7,;-5.08,7.77,;-5.08,9.31,;-6.41,7,;-7.74,7.77,;-1.08,.84,;-1.28,-5.17,;-.51,-6.51,;-2.82,-5.17,;4.08,-3.07,;3.68,-4.55,)|
Structure:
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