Target
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Ligand
BDBM370261
Substrate
n/a
Meas. Tech.
CDK6/Cyclin D1 Mobility Shift Assay
Ki
0.260±n/a nM
Citation
 Behenna, DCChen, PFreeman-Cook, KDHoffman, RLJalaie, MNagata, ANair, SKNinkovic, SOrnelas, MAPalmer, CLRui, EY CDK2/4/6 inhibitors US Patent  US10800783 Publication Date 10/13/2020 
Target
Name:
Cyclin-dependent kinase 6/G1/S-specific cyclin-D1
Synonyms:
CDK6/Cyclin D1
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Component 2
Name:
G1/S-specific cyclin-D1
Synonyms:
CCND1_MOUSE | Ccnd1 | Cyclin D1 | Cyl-1
Type:
Enzyme Subunit
Mol. Mass.:
33418.84
Organism:
Mus musculus (mouse)
Description:
n/a
Residue:
295
Sequence:
MEHQLLCCEVETIRRAYPDTNLLNDRVLRAMLKTEETCAPSVSYFKCVQKEIVPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPLKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEADENKQTIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAMQGLNLGSPNNFLSCYRTTHFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNVDPKATEEEGEVEEEAGLACTPTDVRDVDI
  
Inhibitor
Name:
BDBM370261
Synonyms:
BDBM467156 | US10233188, Example 148
Type:
Small organic molecule
Emp. Form.:
C19H24F3N5O3S
Mol. Mass.:
459.486
SMILES:
CS(=O)(=O)N1CCC(CC1)Nc1ncc2cc(c(=O)n(C3CCCC3)c2n1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: