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Target
Protein Wnt-3a
Ligand
BDBM300688
Substrate
n/a
Meas. Tech.
HCT116 FOPFlash
IC50
24000±n/a nM
Citation
 Thede, K; Scott, W; Bender, E; Golz, S; Hägebarth, A; Lienau, P; Puehler, F; Basting, D; Schneider, D; Möwes, M; Richter, A; Zorn, L; Liu, N; Mönning, U; Siegel, F Compounds US Patent  US10130633 Publication Date 11/20/2018 
Target
Name:
Protein Wnt-3a
Synonyms:
WNT3A | WNT3A_HUMAN
Type:
PROTEIN
Mol. Mass.:
39379.02
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469237
Residue:
352
Sequence:
MAPLGYFLLLCSLKQALGSYPIWWSLAVGPQYSSLGSQPILCASIPGLVPKQLRFCRNYVEIMPSVAEGIKIGIQECQHQFRGRRWNCTTVHDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTAAICGCSSRHQGSPGKGWKWGGCSEDIEFGGMVSREFADARENRPDARSAMNRHNNEAGRQAIASHMHLKCKCHGLSGSCEVKTCWWSQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRPRYTYFKVPTERDLVYYEASPNFCEPNPETGSFGTRDRTCNVSSHGIDGCDLLCCGRGHNARAERRREKCRCVFHWCCYVSCQECTRVYDVHTCK
  
Inhibitor
Name:
BDBM300688
Synonyms:
4-(methoxymethyl)-N-[5-(2- methylphenyl)-1,3,4-thiadiazol- 2-yl]-3-({[1-(4-methylpiperazin- 1-yl)cyclopropyl]carbonyl} amino)benzamide trifluoroacetate (1:1) | US10130633, Example 258
Type:
Small organic molecule
Emp. Form.:
C27H32N6O3S
Mol. Mass.:
520.646
SMILES:
COCc1ccc(cc1NC(=O)C1(CC1)N1CCN(C)CC1)C(=O)Nc1nnc(s1)-c1ccccc1C |$;;;;;;;;;;;;;;;;;;;;;;;;HN;;;;;;;;;;;;$|
Structure:
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