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Target
Disabled homolog 2
Ligand
BDBM62839
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
Ki
779±n/a nM
Citation
 Madden, DR Dab2 inhibitors for the prevention and treatment of cystic fibrosis US Patent  US10864248 Publication Date 12/15/2020 
Target
Name:
Disabled homolog 2
Synonyms:
Adaptor molecule disabled-2 | DAB2 | DAB2_HUMAN | DOC-2 | DOC2 | Differentially expressed in ovarian carcinoma 2 | Differentially-expressed protein 2
Type:
Protein
Mol. Mass.:
82438.29
Organism:
Human
Description:
P98082
Residue:
770
Sequence:
MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA
  
Inhibitor
Name:
BDBM62839
Synonyms:
5,5-dimethyl-2,6-dihydro-[1,2,4]triazol[3,4-a]isoquinoline-3-thione | 5,5-dimethyl-2,6-dihydro-[1,2,4]triazolo[3,4-a]isoquinoline-3-thione | MLS000107006 | SMR000111380 | US10864248, Compound 3 | cid_870599
Type:
Small organic molecule
Emp. Form.:
C12H13N3S
Mol. Mass.:
231.317
SMILES:
CC1(C)Cc2ccccc2-c2n[nH]c(=S)n12
Structure:
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