Reaction Details Report a problem with these data
Target
Fatty acid 2-hydroxylase
Ligand
BDBM483663
Substrate
n/a
Meas. Tech.
In Vitro Competitive Activity-Based Protein Profiling
IC50
550±n/a nM
Citation
 Grice, CA; Wiener, JJ; Weber, OD; Duncan, KK Pyrazole MAGL inhibitors US Patent  US10927105 Publication Date 2/23/2021 
Target
Name:
Fatty acid 2-hydroxylase
Synonyms:
FA2H | FA2H_HUMAN | FAAH | FAXDC1 | Fatty acid alpha-hydroxylase | Fatty acid hydroxylase domain-containing protein 1
Type:
Protein
Mol. Mass.:
42806.38
Organism:
Human
Description:
Q7L5A8
Residue:
372
Sequence:
MAPAPPPAASFSPSEVQRRLAAGACWVRRGARLYDLSSFVRHHPGGEQLLRARAGQDISADLDGPPHRHSANARRWLEQYYVGELRGEQQGSMENEPVALEETQKTDPAMEPRFKVVDWDKDLVDWRKPLLWQVGHLGEKYDEWVHQPVTRPIRLFHSDLIEGLSKTVWYSVPIIWVPLVLYLSWSYYRTFAQGNVRLFTSFTTEYTVAVPKSMFPGLFMLGTFLWSLIEYLIHRFLFHMKPPSDSYYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASLVIGVFYLCMQLILPEAVGGTVFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYSLKAHHVKHHFAHQKSGFGISTKLWDYCFHTLTPEKPHLKTQ
  
Inhibitor
Name:
BDBM483663
Synonyms:
4-chloro-1-(4-(((5- chloro-2- (trifluoromethyl)- benzyl)(methyl)- amino)- methyl)piperidine-1- carbonyl)-1H- pyrazole-3- carboxylic acid | US10927105, Ex 54 | US11655217, Example 54
Type:
Small organic molecule
Emp. Form.:
C20H21Cl2F3N4O3
Mol. Mass.:
493.307
SMILES:
CN(CC1CCN(CC1)C(=O)n1cc(Cl)c(n1)C(O)=O)Cc1cc(Cl)ccc1C(F)(F)F
Structure:
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