Target
Bone morphogenetic protein receptor type-1A [198-525]
Ligand
BDBM451789
Substrate
n/a
Meas. Tech.
ADPGlo Assay
IC50
260±n/a nM
Citation
 Arista, LBabu, SBian, JCui, KDillon, MPLattmann, RLi, JLiao, LLizos, DRamos, RStiefl, NJUllrich, TUsselmann, PWang, XWaykole, LMWeiler, SZhang, YZhou, YZhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent  US10947218 Publication Date 3/16/2021 
Target
Name:
Bone morphogenetic protein receptor type-1A [198-525]
Synonyms:
ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK3) (aa 198-525) | Activin receptor-like kinase 3 (ALK3)(198-525) | BMPR1A | BMR1A_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37140.17
Organism:
Homo sapiens (Human)
Description:
aa 198-525
Residue:
328
Sequence:
AFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMV
  
Inhibitor
Name:
BDBM451789
Synonyms:
US10710980, Example 21 | US10947218, Example 21
Type:
Small organic molecule
Emp. Form.:
C28H35FN4O3
Mol. Mass.:
494.6009
SMILES:
Nc1ncc(cc1C(=O)N[C@@H]1CC[C@@H](O)[C@@H](F)C1)-c1ccc(cc1)[C@@]12C[C@@H]1CN(C2)C1CCOCC1 |r|
Structure:
Search PDB for entries with ligand similarity: