Target
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Ligand
BDBM489185
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
17.5±n/a nM
Citation
 Osborne, SLarge, J Oxazole derivatives for use in the treatment of cancer US Patent  US10961233 Publication Date 3/30/2021 
Target
Name:
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Synonyms:
ADE2 | AIRC | Multifunctional protein ADE2 | PAICS | PAIS | PUR6_HUMAN
Type:
Protein
Mol. Mass.:
47081.21
Organism:
Human
Description:
P22234
Residue:
425
Sequence:
MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKITSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYKFYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSWLPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPEGLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVTSAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQDVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKIRECNL
  
Inhibitor
Name:
BDBM489185
Synonyms:
US10961233, Example 24
Type:
Small organic molecule
Emp. Form.:
C20H27BrN6O4
Mol. Mass.:
495.37
SMILES:
CN(C)CCCOC(=O)N1CCN(CC1)c1ccc(Br)c(NC(=O)c2coc(N)n2)c1
Structure:
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