Target
Stimulator of interferon genes protein [H232R]
Ligand
BDBM490800
Substrate
n/a
Meas. Tech.
Surface Plasmon Resonance (SPR) Binding
Kd
117±n/a nM
Citation
 Wythes, MJMcAlpine, IJPatman, RRui, EYMaderna, AJalaie, MGajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent  US10968242 Publication Date 4/6/2021 
Target
Name:
Stimulator of interferon genes protein [H232R]
Synonyms:
ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein STING (H232R) | TMEM173
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42215.19
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
379
Sequence:
MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS
  
Inhibitor
Name:
BDBM490800
Synonyms:
9,9′-((4S,6R,7S,11aR,13R,14R,14aR,15R)-14-fluoro-2,9,15-trihydroxy-2,9-dioxidooctahydro-11H-4,7-methanofuro[3,2-d][1,3,7,9]tetraoxa[2,8]diphosphacyclotridecine-6,13-diyl)bis(1-methyl-1,9-dihydro-6H-purin-6-one) | US10968242, Example 22
Type:
Small organic molecule
Emp. Form.:
C22H25FN8O12P2
Mol. Mass.:
674.4262
SMILES:
Cn1cnc2n(cnc2c1=O)[C@@H]1C[C@@H]2OP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3F)n1cnc2c1ncn(C)c2=O |r|
Structure:
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