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Target
ADP-ribosylhydrolase ARH3
Ligand
BDBM421497
Substrate
n/a
Meas. Tech.
ARH3 Assay
IC50
76700±n/a nM
Citation
 McGonagle, AE; Jordan, AM; Waszkowycz, B; Hutton, CP; Waddell, ID; Hitchin, JR; Smith, KM; Hamilton, NM PARG inhibitory compounds US Patent  US10995073 Publication Date 5/4/2021 
Target
Name:
ADP-ribosylhydrolase ARH3
Synonyms:
ADP-ribose glycohydrolase ARH3 | ADP-ribosylhydrolase 3 | ADPRHL2 | ADPRS | ADPRS_HUMAN | ARH3 | O-acetyl-ADP-ribose deacetylase ARH3 | Poly(ADP-ribose) glycohydrolase ARH3 | [Protein ADP-ribosylarginine] hydrolase-like protein 2 | [Protein ADP-ribosylserine] hydrolase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
38934.22
Organism:
Homo sapiens (Human)
Description:
Q9NX46
Residue:
363
Sequence:
MAAAAMAAAAGGGAGAARSLSRFRGCLAGALLGDCVGSFYEAHDTVDLTSVLRHVQSLEPDPGTPGSERTEALYYTDDTAMARALVQSLLAKEAFDEVDMAHRFAQEYKKDPDRGYGAGVVTVFKKLLNPKCRDVFEPARAQFNGKGSYGNGGAMRVAGISLAYSSVQDVQKFARLSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLKQLLGHMEDLEGDAQSVLDARELGMEERPYSSRLKKIGELLDQASVTREEVVSELGNGIAAFESVPTAIYCFLRCMEPDPEIPSAFNSLQRTLIYSISLGGDTDTIATMAGAIAGAYYGMDQVPESWQQSCEGYEETDILAQSLHRVFQKS
  
Inhibitor
Name:
BDBM421497
Synonyms:
US10508086, Example 87 | US10995073, Example 87
Type:
Small organic molecule
Emp. Form.:
C20H22N6O3S3
Mol. Mass.:
490.622
SMILES:
Cc1nnc(s1)-n1c2cc(ccc2n(Cc2sc(C)nc2C)c1=O)S(=O)(=O)NC1(C)CC1
Structure:
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