Reaction Details Report a problem with these data
Target
GTPase KRas [G12D,Q61H]
Ligand
BDBM485659
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
7500±n/a nM
Citation
 Hadari, YR; Carta, L; Schmertzler, M; Williams, TM; Reynolds, CH; Hutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease US Patent  US11000515 Publication Date 5/11/2021 
Target
Name:
GTPase KRas [G12D,Q61H]
Synonyms:
GTPase KRas (G12D, Q61H) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21722.64
Organism:
Homo sapiens (Human)
Description:
P01116[G12D,Q61H]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM485659
Synonyms:
US10940139, Example 02680 | US11000515, Compound TABLE 7.231 | US11213515, TABLE 7.231 | US11541041, Compound Table 7.210
Type:
Small organic molecule
Emp. Form.:
C22H19N5O2S
Mol. Mass.:
417.484
SMILES:
Oc1nc(nc2c(csc12)C(=O)N1CCN(CC1)c1ccccc1)-c1ccccn1
Structure:
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