Target
GTPase KRas [G12D,Q61H]
Ligand
BDBM485669
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
20500±n/a nM
Citation
 Hadari, YRCarta, LSchmertzler, MWilliams, TMReynolds, CHHutcheson, R Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease US Patent  US11000515 Publication Date 5/11/2021 
Target
Name:
GTPase KRas [G12D,Q61H]
Synonyms:
GTPase KRas (G12D, Q61H) | KRAS | KRAS2 | RASK2 | RASK_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21722.64
Organism:
Homo sapiens (Human)
Description:
P01116[G12D,Q61H]
Residue:
189
Sequence:
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGCVKIKKCIIM
  
Inhibitor
Name:
BDBM485669
Synonyms:
US10940139, Example 02800 | US11000515, Compound TABLE 7.351 | US11213515, TABLE 7.351 | US11541041, Compound Table 7.330
Type:
Small organic molecule
Emp. Form.:
C12H8ClN3O2S
Mol. Mass.:
293.729
SMILES:
OCc1ccnc(c1)-c1nc(O)c2c(Cl)csc2n1
Structure:
Search PDB for entries with ligand similarity: