Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK1 [850-1154]
Ligand
BDBM103735
Substrate
n/a
Meas. Tech.
JAK1 Inhibition Assay
IC50
334±n/a nM
Citation
 Menet, CJ; Smits, KK Compound useful for the treatment of degenerative and inflammatory diseases US Patent  US11000528 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase JAK1 [850-1154]
Synonyms:
JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Tyrosine-protein kinase JAK1 (850-1154)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
34949.64
Organism:
n/a
Description:
aa 850-1154
Residue:
305
Sequence:
EQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
 
Inhibitor
Name:
BDBM103735
Synonyms:
US10206907, Compound 141 | US11000528, Cpd # 9 | US8563545, 9
Type:
Small organic molecule
Emp. Form.:
C23H26N6O2
Mol. Mass.:
418.4915
SMILES:
CC(=O)N1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Structure:
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