Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase JAK3 [781-1124]
Ligand
BDBM103737
Substrate
n/a
Meas. Tech.
JAK3 Inhibition Assay
IC50
195±n/a nM
Citation
 Menet, CJ; Smits, KK Compound useful for the treatment of degenerative and inflammatory diseases US Patent  US11000528 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein kinase JAK3 [781-1124]
Synonyms:
JAK3 | JAK3 (aa 781-1124) | JAK3_HUMAN | Janus kinase 3 (JAK3) | Tyrosine-protein kinase JAK3 | Tyrosine-protein kinase JAK3 (781-1124) | Tyrosine-protein kinase JAK3 (aa 781-1124)
Type:
n/a
Mol. Mass.:
38772.27
Organism:
Homo sapiens (Human)
Description:
P52333[781-1124]
Residue:
344
Sequence:
ISSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELFTYCDKSCSPSAEFLRMMGCERDVPALCRLLELLEEGQRLPAPPACPAEVHELMKLCWAPSPQDRPSFSALGPQLDMLWSGSRGCETHAFTAHPEGKHHSLSFS
  
Inhibitor
Name:
BDBM103737
Synonyms:
US10206907, Compound 234 | US11000528, Cpd # 11 | US8563545, 11
Type:
Small organic molecule
Emp. Form.:
C22H23F2N5O
Mol. Mass.:
411.4477
SMILES:
FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Structure:
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