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Target
Serine protease HTRA1
Ligand
BDBM496994
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
0.667±n/a nM
Citation
 Hornsperger, B; Maerki, HP; Mohr, P; Reutlinger, M; Rudolph, M Difluoroketamide derivatives as HTRA1 inhibitors US Patent  US11001555 Publication Date 5/11/2021 
Target
Name:
Serine protease HTRA1
Synonyms:
HTRA | HTRA1 | HTRA1_HUMAN | PRSS11
Type:
Protein
Mol. Mass.:
51293.95
Organism:
Homo sapiens (Human)
Description:
Q92743
Residue:
480
Sequence:
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
  
Inhibitor
Name:
BDBM496994
Synonyms:
US11001555, Example 17
Type:
Small organic molecule
Emp. Form.:
C36H37ClF5N5O7S
Mol. Mass.:
814.218
SMILES:
CC(C)[C@H](NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1ccccn1)S(=O)(=O)Cc1ccccc1)C(=O)C(F)(F)C(=O)NCC(F)(F)F
Structure:
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