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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497006
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
37.0±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497006
Synonyms:
US11001561, Compound 3b
Type:
Small organic molecule
Emp. Form.:
C20H24Cl2N4O2
Mol. Mass.:
423.336
SMILES:
C[C@H]1OCC2(CCN(CC2)c2cc(=O)n(c(C)n2)-c2cccc(Cl)c2Cl)[C@@H]1N |r,wU:1.0,wD:26.30,(8.15,.4,;6.66,,;6.19,-1.46,;4.65,-1.46,;4.17,,;3.4,-1.33,;1.86,-1.33,;1.09,,;1.86,1.33,;3.4,1.33,;-.45,,;-1.22,-1.33,;-2.76,-1.33,;-3.53,-2.67,;-3.53,,;-2.76,1.33,;-3.53,2.67,;-1.22,1.33,;-5.07,,;-5.84,-1.33,;-7.38,-1.33,;-8.15,,;-7.38,1.33,;-8.15,2.67,;-5.84,1.33,;-5.07,2.67,;5.42,.91,;5.42,2.45,)|
Structure:
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