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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497012
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1100±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497012
Synonyms:
US11001561, Compound 8
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2F2N5O
Mol. Mass.:
444.306
SMILES:
N[C@@H]1CC(F)(F)CC11CCN(CC1)c1cc(=O)n(c(N)n1)-c1cccc(Cl)c1Cl |r,wD:1.0,(4.82,2.69,;5.3,1.22,;6.76,.75,;6.76,-.79,;8.25,-.39,;7.53,-2.13,;5.3,-1.27,;4.39,-.02,;3.62,-1.36,;2.08,-1.36,;1.31,-.02,;2.08,1.31,;3.62,1.31,;-.23,-.02,;-1,-1.36,;-2.54,-1.36,;-3.31,-2.69,;-3.31,-.02,;-2.54,1.31,;-3.31,2.65,;-1,1.31,;-5.17,-.76,;-5.94,-2.1,;-7.48,-2.1,;-8.25,-.76,;-7.48,.57,;-8.25,1.91,;-5.94,.57,;-5.17,1.91,)|
Structure:
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