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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497019
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
2100±n/a nM
Citation
Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent US11001561 Publication Date 5/11/2021
More Info.:
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Inhibitor
Name:
BDBM497019
Synonyms:
US11001561, Compound 15 | US11702392, Compound 15
Type:
Small organic molecule
Emp. Form.:
C21H26Cl2N4O
Mol. Mass.:
421.363
SMILES:
Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC2(CCCC2CN)CC1 |(-2.72,2.1,;-1.95,.77,;-.41,.77,;.36,-.57,;-.41,-1.9,;-1.95,-1.9,;-2.72,-3.23,;-2.72,-.57,;-4.26,-.57,;-5.03,.77,;-6.57,.77,;-7.34,-.57,;-6.57,-1.9,;-7.34,-3.23,;-5.03,-1.9,;-4.26,-3.23,;1.9,-.57,;2.67,-1.9,;4.21,-1.9,;4.98,-.57,;5.88,-1.81,;7.34,-1.34,;7.34,.2,;5.88,.68,;5.4,2.14,;6.49,3.23,;4.21,.77,;2.67,.77,)|