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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497030
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
14000±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497030
Synonyms:
US11001561, Compound 25
Type:
Small organic molecule
Emp. Form.:
C20H21Cl2F3N4O
Mol. Mass.:
461.308
SMILES:
Cc1nc(N2C[C@@H]3CCC[C@]3(CN)C2)c(c(=O)n1-c1cccc(Cl)c1Cl)C(F)(F)F |r,wU:6.5,wD:10.11,(-.05,3.47,;-.05,1.93,;1.28,1.15,;1.28,-.38,;2.62,-1.15,;2.78,-2.69,;4.28,-3.01,;5.31,-4.15,;6.72,-3.52,;6.56,-1.99,;5.05,-1.67,;5.82,-.34,;5.05,.99,;4.02,-.53,;-.05,-1.15,;-1.39,-.38,;-2.72,-1.15,;-1.39,1.15,;-2.72,1.93,;-2.72,3.47,;-4.05,4.23,;-5.39,3.47,;-5.39,1.93,;-6.72,1.15,;-4.05,1.15,;-4.05,-.38,;-.05,-2.69,;-.05,-4.23,;-1.39,-3.47,;1.28,-3.47,)|
Structure:
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