Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497039
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
5700±n/a nM
Citation
 Jorand-Lebrun, CBoivin, RJohnson, TWang, YXiao, YChen, XLinde, NMusch, DKumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497039
Synonyms:
US11001561, Compound 33a | US11001561, Compound 33b | US11702392, Compound 33b
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2FN4O
Mol. Mass.:
399.29
SMILES:
Cc1nc(cc(=O)n1-c1c(F)ccc(Cl)c1Cl)N1CCC(C)(CN)CC1 |(-1.33,-14.63,;,-13.86,;,-12.32,;1.33,-11.55,;2.67,-12.32,;2.67,-13.86,;4,-14.63,;1.33,-14.63,;1.33,-16.17,;,-16.94,;-1.33,-16.17,;,-18.48,;1.33,-19.25,;2.67,-18.48,;4,-19.25,;2.67,-16.94,;4,-16.17,;1.33,-10.01,;2.67,-9.24,;2.67,-7.7,;1.33,-6.93,;2.32,-5.75,;.34,-5.75,;.87,-4.3,;,-7.7,;,-9.24,)|
Structure:
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