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Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497041
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
1700±n/a nM
Citation
 Jorand-Lebrun, C; Boivin, R; Johnson, T; Wang, Y; Xiao, Y; Chen, X; Linde, N; Musch, D; Kumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497041
Synonyms:
US11001561, Compound 34 | US11702392, Compound 34
Type:
Small organic molecule
Emp. Form.:
C19H22Cl2N4O2
Mol. Mass.:
409.31
SMILES:
Cc1nc(N2C[C@H]3COC[C@@]3(CN)C2)c(C)c(=O)n1-c1cccc(Cl)c1Cl |r,wU:6.5,wD:10.11,(-.05,4.18,;-.05,2.64,;1.28,1.87,;1.28,.33,;2.62,-.44,;4.02,.19,;5.05,-.95,;6.56,-1.27,;6.72,-2.81,;5.31,-3.43,;4.28,-2.29,;3.51,-3.62,;4.28,-4.95,;2.78,-1.97,;-.05,-.44,;-.05,-1.98,;-1.39,.33,;-2.72,-.44,;-1.39,1.87,;-2.72,2.64,;-2.72,4.18,;-4.05,4.95,;-5.39,4.18,;-5.39,2.64,;-6.72,1.87,;-4.05,1.87,;-4.05,.33,)|
Structure:
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