Target
Tyrosine-protein phosphatase non-receptor type 11
Ligand
BDBM497058
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
560±n/a nM
Citation
 Jorand-Lebrun, CBoivin, RJohnson, TWang, YXiao, YChen, XLinde, NMusch, DKumar, D Pyrimidinone derivatives as SHP2 antagonists US Patent  US11001561 Publication Date 5/11/2021 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 11
Synonyms:
PTN11_HUMAN | PTP-1D | PTP-2C | PTP2C | PTPN11 | Protein Tyrosine Phosphatase PPN11/Shp2 | Protein tyrosine phosphatase (PTP) Shp2 | Protein-Tyrosine Phosphatase SHP-2 | Protein-tyrosine phosphatase 2C | SH-PTP3 | SHP2 | SHPTP2 | Src homology phosphatase 2 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 | Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) | Tyrosine-protein phosphatase non-receptor type 11 (SHP-2) | Tyrosine-protein phosphatase non-receptor type 11 (SHP2)
Type:
Protein phosphatase
Mol. Mass.:
68443.59
Organism:
Homo sapiens (Human)
Description:
Q06124
Residue:
597
Sequence:
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
  
Inhibitor
Name:
BDBM497058
Synonyms:
US11001561, Compound 50 | US11702392, Compound 50
Type:
Small organic molecule
Emp. Form.:
C24H32Cl2N4O2
Mol. Mass.:
479.442
SMILES:
Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC(C)(CC1)NCC1CCC(O)CC1 |(-5.54,2.46,;-4.77,1.13,;-3.23,1.13,;-2.46,-.21,;-3.23,-1.54,;-4.77,-1.54,;-5.54,-2.87,;-5.54,-.21,;-7.08,-.21,;-7.85,1.13,;-9.39,1.13,;-10.16,-.21,;-9.39,-1.54,;-10.16,-2.87,;-7.85,-1.54,;-7.08,-2.87,;-.92,-.21,;-.15,-1.54,;1.39,-1.54,;2.16,-.21,;3.49,-.98,;1.39,1.13,;-.15,1.13,;3.49,.56,;4.83,-.21,;6.16,.56,;7.49,-.21,;8.83,.56,;8.83,2.1,;10.16,2.87,;7.49,2.87,;6.16,2.1,)|
Structure:
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